ADE, OAS, MISC-C etc.

Children are not at Risk from COVID-19

Only a small fraction of children and adolescents below age 18 has got severe form of COVID-19, and almost all of them had chronic conditions putting them at risk. Per Characteristics and Disease Severity of US Children and Adolescents Diagnosed With COVID-19 [a1], at least 84% of people below 19, hospitalized with severe COVID-19, had chronic conditions. The total number was 756 (March – October 2020), out of almost two million children and adults of the same age, hospitalized or seen in ER in that period.

It is confirmed in Children and young people remain at low risk of COVID-19 mortality [a2]:

“With the caveat that some children at high risk might be using extreme so-called shielding measures, children are overall not becoming seriously unwell with COVID-19

In the US, only 287 COVID-19 deaths were registered among children and adolescents below 18 by May 12, 2021 [a3]. Almost all these deaths were adolescents 14-17 with chronic conditions. It is not sure that even one 12-year-old has died from COVID-19. Despite these statistics, somebody decided to start mass vaccination of 12-year-olds.

Here, the phrase “at risk” is used as it is normally understood, i.e., trivial risks are excluded.

[a1] Characteristics and Disease Severity of US Children and Adolescents Diagnosed With COVID-19. Preston LE, Chevinsky JR, Kompaniyets L, et al., JAMA Network Open, April 9, 2021

[a2] Children and young people remain at low risk of COVID-19 mortality, Bhopal, Sunil S et al., The Lancet Child & Adolescent Health, March 10, 2021

[a3] Statista Report, May 2021

Professional Opinion

Many medical experts oppose vaccinating children against COVID-19 and are raising numerous concerns regarding the long term effects of the vaccines. These voices are effectively being silenced both by the current administration and by Google, Facebook, Twitter, Microsoft, and Apple, who deplatform and otherwise silence them.

ADE

Antibody-developed enhancement (ADE)[1]  is when neutralizing antibodies cannot fully neutralize the coronavirus and sometimes, even help it. This problem sank attempts to develop vaccines[2] against SARS-COV-1 (twin brother of SARS-COV-2) and MERS (its cousin). The Pfizer and Moderna vaccines cause the body to create a huge amount of antibodies, which neutralize even partially resistant variants. Antibodies amount starts dropping After about 6-9 months after vaccination, the titer of vaccine produced antibodies decreases. It is thus very likely that individuals with anti-spike immunity who encounter a resistant variant of the virus, will develop ADE.

The main purpose of a vaccine is to create immunity memory (T and B cells), which lasts after the antibodies have waned. Individuals with immunity elicited by an anti-spike protein vaccine will first react by targeting the spike protein of any virus variants they encounter. Furthermore, the response will be to the old variant of the spike protein, not the new one – a phenomenon known as original antigenic sin[3] [4]. If the reaction is successful, because the spike protein of the virus is still the same), the virus would be neutralized before the body can develop normal broad spectrum immunity, not limited to spike protein. If the reaction is not successful, because the spike has mutated, the ineffective neutralizing antibodies are likely to cause ADE. Younger people are more likely to have worse reactions, especially if they had not developed immunity by exposure before vaccination.

These effects cannot be observed within the first 4-6 months after vaccination. Pfizer and Moderna are developing booster shots, with capacity against vaccine-resistant variants[5]. Even if they succeed, all those vaccinated (especially children) effectively become dependent on new booster shots. Who wants to live in  constant fear of an ever-mutating virus, requiring another shot every time a new COVID variant appears?

A recent research paper suggests an ‘original antigenic sin like’ impact on immune reaction to common cold coronaviruses. Some kids/adolescent might not have had many encounters with common cold coronaviruses. Thus, the COVID-19 vaccines might cripple not only their immune response to COVID-19, but also to common colds. Also, this paper suggests that the COVID-19 anti-spike vaccine elicits a lower ratio of neutralizing antibodies, strengthening the case for vaccine induced ADE.

[1] https://link.springer.com/article/10.1134/S0006350920040119

[2] https://www.frontiersin.org/articles/10.3389/fimmu.2021.640093/full

[3] https://www.sciencedirect.com/science/article/abs/pii/S0896841117302226

[4] https://www.frontiersin.org/articles/10.3389/fimmu.2020.01120/full

[5] https://www.clinicaltrialsarena.com/comment/new-sars-cov-2-variants-push-covid-19-vaccine-long-term-durability

MIS-C

MIS-C is Multisystem Inflammatory Syndrome in children, following COVID-19 in very rare cases. Its other name is PIMS-TS (Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2). Multiple scientists believe it to to be caused by by ADE.

Two Different Antibody-Dependent Enhancement (ADE) Risks for SARS-CoV-2 Antibodies, Darrell O. Ricke, Frontiers in Immunology, February 2021

“Antibody-dependent enhancement (ADE) may be involved in the clinical observation of increased severity of symptoms associated with early high levels of SARS-CoV-2 antibodies in patients. Infants with multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 may also have ADE caused by maternally acquired SARS-CoV-2 antibodies bound to mast cells. … SARS-CoV-2 antibodies bound to Fc receptors on macrophages and mast cells may represent two different mechanisms for ADE in patients.”
“Vaccine-associated enhanced disease (VAED) can result when there are multiple circularizing serotypes of virus or when the virus uses antibodies for expanded host cell trophism of phagocytic immune cells.”
“Given past data on multiple SARS-CoV-1 and MERS-CoV vaccine efforts have failed due to ADE in animal models, it is reasonable to hypothesize a similar ADE risk for SARS-CoV-2 antibodies and vaccines. ADE risks may be associated with antibody level (which can wane over time after vaccination) and also if the antibodies are derived from prior exposures to other coronaviruses”

Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2: a New Challenge amid the Pandemic. Lawrensia, S., Henrina, J., Wijaya, E. et al. SN Compr. Clin. Med. October 2020.

“The first possible hypothesis is that PIMS-TS is an immunologically mediated pathogenesis or a post-infectious process caused by non-neutralizing IgG antibody through antibody-dependent enhancement (ADE). The reported cases of PIMS-TS emerged after the peak of SARS-CoV-2 infection in some countries. They found that most patients were more often had a positive test for antibody to SARS-CoV-2 than for the virus using nasopharyngeal RT-PCR, which raises the possibility of the involvement of acquired immunity aberrant development. This evidence is supported by the finding from a large multicentre observational study among 78 children … . This result supports the evidence that PIMS-TS might not be an acute COVID-19 infection, but it is more likely a post-immunological reaction.”

 

Originally published on May 27. MIS-C added on May 31.

via Science Defies Politics

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May 31, 2021 at 12:01PM

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