Science Also a Pandemic Victim

John P.A. Ioannidis writes at The Tablet How the Pandemic Is Changing the Norms of Science. Excerpts in italics with my bolds aand some added images.

Imperatives like skepticism and disinterestedness are being junked to fuel political warfare that has nothing in common with scientific methodology

Before the pandemic, the sharing of data, protocols, and discoveries for free was limited, compromising the communalism on which the scientific method is based. It was already widely tolerated that science was not universal, but the realm of an ever-more hierarchical elite, a minority of experts. Gargantuan financial and other interests and conflicts thrived in the neighborhood of science—and the norm of disinterestedness was left forlorn.

As for organized skepticism, it did not sell very well within academic sanctuaries. Even the best peer-reviewed journals often presented results with bias and spin. Broader public and media dissemination of scientific discoveries was largely focused on what could be exaggerated about the research, rather than the rigor of its methods and the inherent uncertainty of the results.

Nevertheless, despite the cynical realization that the methodological norms of science had been neglected (or perhaps because of this realization), voices struggling for more communalism, universalism, disinterestedness, and organized skepticism had been multiplying among scientific circles prior to the pandemic. Reformers were often seen as holding some sort of a moral higher ground, despite being outnumbered in occupancy of powerful positions. Reproducibility crises in many scientific fields, ranging from biomedicine to psychology, caused soul-searching and efforts to enhance transparency, including the sharing of raw data, protocols, and code. Inequalities within the academy were increasingly recognized with calls to remedy them. Many were receptive to pleas for reform.

Opinion-based experts (while still dominant in influential committees, professional societies, major conferences, funding bodies, and other power nodes of the system) were often challenged by evidence-based criticism. There were efforts to make conflicts of interest more transparent and to minimize their impact, even if most science leaders remained conflicted, especially in medicine. A thriving community of scientists focused on rigorous methods, understanding biases, and minimizing their impact. The field of metaresearch, i.e., research on research, had become widely respected. One might therefore have hoped that the pandemic crisis could have fostered change.

Indeed, change did happen—but perhaps mostly for the worst.

Lack of communalism during the pandemic fueled scandals and conspiracy theories, which were then treated as fact in the name of science by much of the popular press and on social media. The retraction of a highly visible hydroxychloroquine paper from the The Lancet was a startling example: A lack of sharing and openness allowed a top medical journal to publish an article in which 671 hospitals allegedly contributed data that did not exist, and no one noticed this outright fabrication before publication. The New England Journal of Medicine, another top medical journal, managed to publish a similar paper; many scientists continue to heavily cite it long after its retraction.

The pandemic led seemingly overnight to a scary new form of scientific universalism. Everyone did COVID-19 science or commented on it. By August 2021, 330,000 scientific papers were published on COVID-19, involving roughly a million different authors. An analysis showed that scientists from every single one of the 174 disciplines that comprise what we know as science has published on COVID-19. By the end of 2020, only automobile engineering didn’t have scientists publishing on COVID-19. By early 2021, the automobile engineers had their say, too.

Many amazing scientists have worked on COVID-19. I admire their work. Their contributions have taught us so much. My gratitude extends to the many extremely talented and well-trained young investigators who rejuvenate our aging scientific workforce. However, alongside thousands of solid scientists came freshly minted experts with questionable, irrelevant, or nonexistent credentials and questionable, irrelevant, or nonexistent data.

Social and mainstream media have helped to manufacture this new breed of experts. Anyone who was not an epidemiologist or health policy specialist could suddenly be cited as an epidemiologist or health policy specialist by reporters who often knew little about those fields but knew immediately which opinions were true. Conversely, some of the best epidemiologists and health policy specialists in America were smeared as clueless and dangerous by people who believed themselves fit to summarily arbitrate differences of scientific opinion without understanding the methodology or data at issue.

Disinterestedness suffered gravely. In the past, conflicted entities mostly tried to hide their agendas. During the pandemic, these same conflicted entities were raised to the status of heroes.

For example, Big Pharma companies clearly produced useful drugs, vaccines, and other interventions that saved lives, though it was also known that profit was and is their main motive. Big Tobacco was known to kill many millions of people every year and to continuously mislead when promoting its old and new, equally harmful, products. Yet during the pandemic, requesting better evidence on effectiveness and adverse events was often considered anathema. This dismissive, authoritarian approach “in defense of science” may sadly have enhanced vaccine hesitancy and the anti-vax movement, wasting a unique opportunity that was created by the fantastic rapid development of COVID-19 vaccines. Even the tobacco industry upgraded its reputation: Philip Morris donated ventilators to propel a profile of corporate responsibility and saving lives, a tiny fraction of which were put at risk of death from COVID-19 because of background diseases caused by tobacco products.

Other potentially conflicted entities became the new societal regulators, rather than the ones being regulated. Big Tech companies, which gained trillions of dollars in cumulative market value from the virtual transformation of human life during lockdown, developed powerful censorship machineries that skewed the information available to users on their platforms. Consultants who made millions of dollars from corporate and government consultation were given prestigious positions, power, and public praise, while unconflicted scientists who worked pro bono but dared to question dominant narratives were smeared as being conflicted. Organized skepticism was seen as a threat to public health.

There was a clash between two schools of thought, authoritarian public health versus science—and science lost.

Heated but healthy scientific debates are welcome. Serious critics are our greatest benefactors. John Tukey once said that the collective noun for a group of statisticians is a quarrel. This applies to other scientists, too. But “we are at war” led to a step beyond: This is a dirty war, one without dignity. Opponents were threatened, abused, and bullied by cancel culture campaigns in social media, hit stories in mainstream media, and bestsellers written by zealots. Statements were distorted, turned into straw men, and ridiculed. Wikipedia pages were vandalized. Reputations were systematically devastated and destroyed. Many brilliant scientists were abused and received threats during the pandemic, intended to make them and their families miserable.

Politics had a deleterious influence on pandemic science. Anything any apolitical scientist said or wrote could be weaponized for political agendas. Tying public health interventions like masks and vaccines to a faction, political or otherwise, satisfies those devoted to that faction, but infuriates the opposing faction. This process undermines the wider adoption required for such interventions to be effective. Politics dressed up as public health not only injured science.

It also shot down participatory public health where people are empowered, rather than obligated and humiliated.

There was absolutely no conspiracy or preplanning behind this hypercharged evolution. Simply, in times of crisis, the powerful thrive and the weak become more disadvantaged. Amid pandemic confusion, the powerful and the conflicted became more powerful and more conflicted, while millions of disadvantaged people have died and billions suffered.

I worry that science and its norms have shared the fate of the disadvantaged. It is a pity, because science can still help everyone. Science remains the best thing that can happen to humans, provided it can be both tolerant and tolerated.

John P.A. Ioannidis is Professor of Medicine and Professor of Epidemiology and Population Health, as well as Professor (by courtesy) of Biomedical Science and Statistics, at Stanford University. His complete COVID-19-related publications can be found here.


via Science Matters

September 14, 2021 at 12:31PM

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